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[a] Sketch of FWM epi-detected microscope with heterodyne interferometry implemented [b] Sketch of polymer coated 15nm AuNP. The polymer has attached fluorescently labelled ligand (Transferrin-AlexaFluor488) in order to follow the endocytic pathway inside HeLa cells. [c] DIC image of HeLa cells obtained at the microscope shown in (a) with a 100x, 1.45NA oil objective. FWM imaging was performed on the region drown with dashed rectangular [d] Set of 20x20μm raster scan FWM images show the distribution of the AuNPs in the cell region [e] Maximum Z intensity projection of the confocal fluorescent images indicating highly uptake efficiency of the fluorescently labelled AuNPs compounds.

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